Dr. Al-Shabrawey is an expert in retinal vascular alterations occurring under conditions of ischemic stress. His research seeks to understand the molecular and cellular mechanisms of the pathological retinal neovascularization and vascular leakage in diabetic retinopathy and retinopathy of prematurity, two major causes of blindness in adults and children, respectively. Reactive oxygen species produced by NADPH oxidase mediate pathological neovascularization in ROP as well as diabetic retinopathy. Dr. Al-Shabrawey’s studies of PARPγ were among the first to show a role of this receptor in diabetic retinopathy and its regulation by NADPH oxidase. His lab also investigates arachidonic acid, which is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE), and has an important role in the regulation of angiogenesis, endothelial cell proliferation and migration. Dr. Al-Shabrawey and his team are investigating the role of 12-LOX in retinal neovascularization. Dr. Al-Shabrawey participates in the Fundamentals of Vision Science course, serves on thesis committees for students, and has mentored students and post-doctoral fellows in his lab. He has active collaborations with Drs. Nussbaum, El-Remessy, Liou, Caldwell and Smith.